Effect of nitric oxide scavengers, carboxy-PTIO on endotoxin induced shock in sheep
نویسندگان
چکیده
منابع مشابه
Effects of a nitric oxide scavenger, carboxy-PTIO, on isoflurane MAC and cerebellar nitric oxide synthase activity in rats.
Recent studies have indicated that nitric oxide may play a role in inhalation anaesthesia. Inhibition of nitric oxide synthase reduces the minimum alveolar concentration (MAC) for inhalation anaesthetics and decreases cerebellar nitric oxide synthase (NOS) activity in rats. In this study, we have explored further the role of nitric oxide in isoflurane anaesthesia by examining the effects of a n...
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Reactions of PTIO and Carboxy - PTIO with
Nitronyl nitroxides, such as derivatives of 2-phenyl4,4,5,5,-tetramethylimidazoline-1-oxyl 3-oxide (PTIOs), react with NO to form the corresponding imino nitroxides (PTIs) and NO2. PTIOs are considered as monitors of NO, stoichiometric sources of NO2, biochemical and physiological effectors, specific tools for the elimination of NO, and potential therapeutic agents. However, a better understand...
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BACKGROUND: Nitric oxide (NO) production following bacterial infection may play a physiological role in the host defense mechanism due to its antimicrobial activity. However, excess production of NO in severe infection such as sepsis has been implicated in the pathogenesis of septic shock. To determine whether a nitronyl nitroxide NO scavenger compound could prevent the hemodynamic and blood ga...
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ژورنال
عنوان ژورنال: Ethiopian Journal of Health Development
سال: 2000
ISSN: 1021-6790
DOI: 10.4314/ejhd.v14i1.9933